It is not unfamiliar to receive real time protection (RTP) outbound warnings from your antivirus software when using a Peer-to-Peer (P2P) client. Malwarebytes (RTP) is infamous for this, here is an example of what they may look like.
Peer-to-Peer (P2P) applications connect to many different servers/IP addresses (this is how files are downloaded through P2P Clients ) and because of this, sometimes a P2P Client will connect to a server that is also known for hosting malicious content. This is because servers/IP addresses are often shared by multiple sites, so while what you are downloading through your P2P Client may be perfectly safe, some of the sites hosted on some of the IP addresses that your P2P Client connects to may be malicious. Such connections are not a threat however, and you may exclude your P2P Client from the Web Protection component in your antivirus software to stop the blocks from happening without compromising your protection (your web browser and other critical web facing programs will still be fully protected from malicious websites and other malicious content).